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Repositorio Institucional Continental


Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12394/10017
Title: Multidrug resistance and its association with Enterobacteriales and age among pregnant Peruvian women with- bacteremia
Authors: Quispe, Antonio M.
Soza, Gabriela
Pons, Maria J.
Keywords: Mujeres embarazadas
Drogas
Enfermedades bacterianas
Publisher: Universidad Continental
Issue Date: 2020
Date available: 31-Aug-2021
Bibliographic citation: Quispe, A., Soza G. y Pons, M. (2020). Multidrug resistance and its association with Enterobacteriales and age among pregnant Peruvian women with- bacteremia. Journal of Infection in Developing Countries, 14(12), 1402-1409. https://doi.org/10.3855/jidc.12569
DOI: https://doi.org/10.3855/jidc.12569
Abstract: Introduction: This study aimed to assess the prevalence of multidrug resistance (MDR) and its associated factors among pregnant Peruvian women with bacteremia. Methodology: In an 18-month cross-sectional study, all pregnant women were routinely tested with a presumptive diagnosis of sepsis admitted to the largest reference maternity hospital (Instituto Nacional Materno Perinatal) in Lima, Peru for bacteremia. Every isolate was tested for antimicrobial susceptibility as defined by the Institute of Clinical and Laboratory Standards (CLSI). Additionally, associated factors were assessed with MDR and the number of resistant antimicrobial categories using robust Poisson regression models with link log, especially focused on its association with age and bacterial families or species. Results: A total of 236 blood cultures of pregnant women (33.4 ± 11.4 years old) was analyzed. The prevalence of MDR was 70% (95% confidence interval [CI]: 64%–76%). The main etiological agent was Escherichia coli (65%), showing an MDR rate of 74% (68%–81%). Overall, we observed that the MDR rate was associated with Enterobacteriales (adjusted prevalence rate, (aPR) = 1.29; 95% CI: 1.03–1.61) and age 35 or older (PR = 1.18; 95% CI: 1.01–1.39). However, the number of resistant antimicrobial categories was associated with Enterobacteriales (aPR = 1.44; 95% CI: 1.25–1.67) and hospital-acquired infections (PR = 0.81; 95% CI: 1.01–1.39). Conclusions: The prevalence of MDR among pregnant women with sepsis was alarmingly high, being even higher among women age 35 or older and among those with hospital-acquired infections.
Included in: https://jidc.org/index.php/journal/article/view/33378282
metadata.dc.format.extent: p. 1402-1409
Access: Acceso abierto
Source: Universidad Continental
Repositorio Institucional - Continental
Appears in Collections:Artículos Científicos

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