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Repositorio Institucional Continental

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Title: Pharmacogenomics of Alzheimer's and Parkinson's diseases
Authors: Cacabelos, R.
Keywords: Enfermedad de Alzheimer
Enfermedad de Parkinson
Publisher: Universidad Continental
Issue Date: 1-May-2020
Date available: 1-Jul-2020
Creation date: 2020
Bibliographic citation: Cacabelos, R. (2020). Pharmacogenomics of Alzheimer's and Parkinson's diseases. Neuroscience Letters, 726.
Abstract: Neurodegenerative disorders (NDDs)(Alzheimer’s disease, Parkinson’s disease) represent major problems of health in developed countries, with important psychosocial burden for families and high cost for the society. NDDs share some common pathogenic mechanisms such as age-related decline, multiple genetic defects distributed across the genome, deposits of abnormal proteins in the brain, and diverse environmental risk factors. Patients with NDDs currently receive polypharmacy with a high risk for drug-drug interactions and severe adverse drug events. Pharmacogenomics accounts for 60–90% variability in drug pharmacokinetics and pharmacodynamics. Major determinants of the pharmacogenomic outcome include pathogenic, mechanistic, metabolic, transporter and pleiotropic genes. The expression of these genes is under regulatory control of the epigenetic machinery. Approximately, 80% of the Caucasian population is deficient in the metabolization of drugs due to polymorphisms in metabolic genes; consequently, less than 40% of patients respond appropriately to conventional drugs. The implementation of pharmacogenomic procedures in the clinical practice may help to optimize therapeutics in NDDs.
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metadata.dc.format.extent: [13] páginas
Access: Restringido
Source: Universidad Continental
Repositorio Institucional - Continental
Appears in Collections:Artículos de revisiones

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