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Repositorio Institucional Continental

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Title: Ameliorative Effect of the Oral Administration of Chuquiraga spinosa in a Murine Model of Breast Cancer Induced with 7,12-Dimethylbenz[a]anthracene (DMBA)
Authors: Arroyo-Acevedo, J.L.
Herrera-Calderon, O.
Tinco-Jayo, J.A.
Rojas-Armas, J.P.
Rauf, A.
Hañari-Quispe, R.
Figueroa-Salvador, L.
Fernández-Guzmán, V.
Yuli-Posadas, R.Á.
Keywords: Neoplasias de la Mama
Publisher: Universidad Continental
Issue Date: May-2020
Date available: 2-Jul-2020
Creation date: 2020
Bibliographic citation: Arroyo-Acevedo, J.L., Herrera-Calderon, O., Tinco-Jayo, J.A., Rojas-Armas, J.P., Rauf, A., Hañari-Quispe, R., Figueroa-Salvador, L., Fernández-Guzmán, V., Yuli-Posadas, R.Á. (2020). Ameliorative Effect of the Oral Administration of Chuquiraga spinosa in a Murine Model of Breast Cancer Induced with 7,12-Dimethylbenz[a]anthracene (DMBA). Pharmacognosy Journal, 12(3), 562-568. 10.5530/pj.2020.12.85
DOI: 10.5530/pj.2020.12.85
Abstract: Objective: To determine the ameliorative effect of the ethanolic extract of Chuquiraga spinosa (ChS) on 7,12-Dimethylbenz[a]anthracene (DMBA)-induced breast cancer in rats. Methods: 36 female Holztman rats were divided into 6 groups. I) The negative control group received physiological saline (PS). II) ChS-200 group received 200 mg/kg of ChS. III) DMBA group was induced with DMBA (20 mg/Kg) dissolved in PS and administrated orally for 15 weeks. IV) DMBA + ChS-50 group, V) DMBA + ChS-250 group, and VI) DMBA + ChS-500 group, which received the extract orally for 15 weeks after DMBA induction. All data were expressed as mean and standard deviation. One-way analysis of variance (ANOVA) followed by Dunnet test was carried out to compare the mean value of different groups Histopathological analysis was evaluated by using Image J software. Results: Hematology showed that the triglyceride level was significantly lowered (P< 0.01) and high-density lipoprotein (HDL) level was significantly increased (P <0.01) in groups III, IV and V. Also, ChS extract significantly lowered the C reactive protein (CRP) level (P <0.01) and malondialdehyde level (P<0.05). There was a significant decrease in the frequency of DMBA-induced micronucleated polychromatic erythrocyte (P<0.01). Conclusions: Chuquiraga spinosa showed an ameliorative effect on DMBA-induced breast cancer in rats as well as antioxidant, antitumor and antigenotoxic properties.
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metadata.dc.format.extent: p. 562-568
Access: Acceso abierto
Source: Universidad Continental
Repositorio Institucional - Continental
Appears in Collections:Artículos Científicos

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