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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12394/7834
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dc.contributor.authorCacabelos, R.-
dc.contributor.authorTeijido, O.-
dc.date.accessioned2020-07-17T16:29:15Z-
dc.date.available2020-07-17T16:29:15Z-
dc.date.created2020-
dc.date.issued2018-01-01-
dc.identifier.citationCacabelos, R., Teijido, O. (2018). Epigenetics of brain aging . Conn's Handbook of Models for Human Aging, 1(1), 1041-1065. https://doi. 10.1016/B978-0-12-811353-0.00074-9es_ES
dc.identifier.urihttps://hdl.handle.net/20.500.12394/7834-
dc.description.abstractThe complexity of human aging and longevity results from a combination of genetic, epigenetic, and environmental factors. Epigenetic mechanisms, including DNA methylation, chromatin structure, and RNA interference, regulate gene expression and control the main metabolic pathways throughout life. This strict epigenetic management becomes progressively defective with age, which increases the risk for the onset of age-related pathologies. This chapter reviews the main alterations of the epigenetic machinery throughout life, with special focus on those affecting the aging brain, as well as the epigenetic control of life span by regulating telomere length and mitochondrial function, with special emphasis on the epigenetic interplay between nuclear and mitochondrial DNA. The last section summarizes the main epigenetic aberrations involving the most prevalent form of pathologic brain deterioration in elderly individuals, Alzheimer's disease, and novel potential epigenetic-based treatments.es_ES
dc.formatapplication/pdfes_ES
dc.format.extentp. 1041-1065es_ES
dc.language.isoenges_ES
dc.publisherUniversidad Continentales_ES
dc.relationhttps://www.sciencedirect.com/science/article/pii/B9780128113530000749es_ES
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_ES
dc.sourceUniversidad Continentales_ES
dc.sourceRepositorio Institucional - Continentales_ES
dc.subjectEnvejecimientoes_ES
dc.subjectEstructura de la cromatinaes_ES
dc.titleEpigenetics of brain aginges_ES
dc.title.alternativeEpigenética del envejecimiento cerebrales_ES
dc.typeinfo:eu-repo/semantics/bookPartes_ES
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)es_ES
dc.description.notePara acceder al artículo de su interés, puede solicitarlo a bibliotecario@continental.edu.pe. Por favor comunicarse desde su correo institucional.es_ES
dc.rights.accessRightsRestringidoes_ES
dc.identifier.journalConn's Handbook of Models for Human Aginges_ES
dc.identifier.doi10.1016/B978-0-12-811353-0.00074-9es_ES
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