Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12394/8504
Title: TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes
Authors: Velasco Chong, Jonas Roberto
Oscar Herrera Calderón
Juan Pedro Rojas Armas
Renán Dilton Hañari Quispe
Renán Dilton Hañari Quispe
Gilmar Peña Rojas
Vidalina Andía Ayme
Vidalina Andía Ayme
Andres F. Yepes Perez
Cristian Aguilar
Keywords: Productos agropecuarios
Tocosh
Papas
Fermentación
Publisher: Universidad Continental
Issue Date: 2020
metadata.dc.date.available: 25-Feb-2021
Citation: Velasco, J., Herrera, O., Rojas, J., Hañari, R., Figueroa, l., Peña, G., Andía, V., Yuli, R., Yepes, A., Aguilar, C., (2020). TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes. Foods, 9(6). https://doi.org/10.3390/foods9060719
metadata.dc.identifier.doi: https://doi.org/10.3390/foods9060719
Abstract: Potato tocosh is a naturally processed potato for nutritional and curative purposes from traditional Peruvian medicine. The aim of this study was to investigate the acute and sub-acute toxicity of tocosh flour (TF). For sub-acute toxicity, TF was administered orally to rats daily once a day for 28 days at doses of 1000 mg/kg body weight (BW). Animals were observed for general behaviors, mortality, body weight variations, and histological analysis. At the end of treatment, relative organ weights, histopathology, hematological and biochemical parameters were analyzed. For acute toxicity, TF was administered orally to mice at doses of 2000 and 5000 mg/kg BW at a single dose in both sexes. Body weight, mortality, and clinical signs were observed for 14 days after treatment. The results of acute toxicity showed that the median lethal dose (LD50) value of TF is higher than 2000 g/kg BW but less than 5000 mg/Kg BW in mice. Death and toxicological symptoms were not found during the treatment. For sub-acute toxicity, we found that no-observed-adverse-effect levels (NOAEL) of TF in rats up to 1000 g/kg BW. There were statistically significant differences in body weight, and relative organ weight in the stomach and brain. No differences in hematological and biochemical parameters were observed when compared with the control group. For sub-acute toxicity, histopathological studies revealed minor abnormalities in liver and kidney tissues at doses of 5000 mg/Kg. Based on these results, TF is a traditional Peruvian medicine with high safety at up to 1000 mg/kg BW for 28 days in rats.
metadata.dc.relation: https://www.mdpi.com/2304-8158/9/6/719/htm
Extension: 16 páginas
metadata.dc.rights.accessRights: Acceso abierto
metadata.dc.source: Universidad Continental
Repositorio Institucional - Continental
Appears in Collections:Artículos Científicos

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