Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12394/8504
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dc.contributor.authorVelasco Chong, Jonas Robertoes_ES
dc.contributor.authorOscar Herrera Calderónes_ES
dc.contributor.authorJuan Pedro Rojas Armases_ES
dc.contributor.authorRenán Dilton Hañari Quispees_ES
dc.contributor.authorRenán Dilton Hañari Quispees_ES
dc.contributor.authorGilmar Peña Rojases_ES
dc.contributor.authorVidalina Andía Aymees_ES
dc.contributor.authorVidalina Andía Aymees_ES
dc.contributor.authorAndres F. Yepes Perezes_ES
dc.contributor.authorCristian Aguilares_ES
dc.date.accessioned2021-02-25T18:12:41Z-
dc.date.available2021-02-25T18:12:41Z-
dc.date.issued2020-
dc.identifier.citationVelasco, J., Herrera, O., Rojas, J., Hañari, R., Figueroa, l., Peña, G., Andía, V., Yuli, R., Yepes, A., Aguilar, C., (2020). TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes. Foods, 9(6). https://doi.org/10.3390/foods9060719es_ES
dc.identifier.issn2304-8158es_ES
dc.identifier.urihttps://hdl.handle.net/20.500.12394/8504-
dc.description.abstractPotato tocosh is a naturally processed potato for nutritional and curative purposes from traditional Peruvian medicine. The aim of this study was to investigate the acute and sub-acute toxicity of tocosh flour (TF). For sub-acute toxicity, TF was administered orally to rats daily once a day for 28 days at doses of 1000 mg/kg body weight (BW). Animals were observed for general behaviors, mortality, body weight variations, and histological analysis. At the end of treatment, relative organ weights, histopathology, hematological and biochemical parameters were analyzed. For acute toxicity, TF was administered orally to mice at doses of 2000 and 5000 mg/kg BW at a single dose in both sexes. Body weight, mortality, and clinical signs were observed for 14 days after treatment. The results of acute toxicity showed that the median lethal dose (LD50) value of TF is higher than 2000 g/kg BW but less than 5000 mg/Kg BW in mice. Death and toxicological symptoms were not found during the treatment. For sub-acute toxicity, we found that no-observed-adverse-effect levels (NOAEL) of TF in rats up to 1000 g/kg BW. There were statistically significant differences in body weight, and relative organ weight in the stomach and brain. No differences in hematological and biochemical parameters were observed when compared with the control group. For sub-acute toxicity, histopathological studies revealed minor abnormalities in liver and kidney tissues at doses of 5000 mg/Kg. Based on these results, TF is a traditional Peruvian medicine with high safety at up to 1000 mg/kg BW for 28 days in rats.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent16 páginases_ES
dc.language.isoenges_ES
dc.publisherUniversidad Continentales_ES
dc.relationhttps://www.mdpi.com/2304-8158/9/6/719/htmes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceUniversidad Continentales_ES
dc.sourceRepositorio Institucional - Continentales_ES
dc.subjectProductos agropecuarioses_ES
dc.subjectTocoshes_ES
dc.subjectPapases_ES
dc.subjectFermentaciónes_ES
dc.titleTOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoeses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)es_ES
dc.rights.accessRightsAcceso abiertoes_ES
dc.identifier.journalFoodses_ES
dc.identifier.doihttps://doi.org/10.3390/foods9060719es_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#4.01.01es_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
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