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dc.contributor.authorMorante, Jasminees_ES
dc.contributor.authorQuispe, Antonio M.es_ES
dc.contributor.authorYmaña, Barbaraes_ES
dc.contributor.authorMoya-Salazar, Jeeles_ES
dc.contributor.authorLuque, Néstores_ES
dc.contributor.authorSoza, Gabrielaes_ES
dc.contributor.authorRamos Chirinos, Maríaes_ES
dc.contributor.authorPons, Maria J.es_ES
dc.identifier.citationMorante, J., Quispe, A., Ymaña, B., Moya, J., Luque, N., Soza, G., Ramos, M., Pons, M. (2021). Tolerance to disinfectants (chlorhexidine and isopropanol) and its association with antibiotic resistance in clinically-related Klebsiella pneumoniae isolates. Pathogens and Global Health, 1(1),
dc.description.abstractDisinfectants play an essential role in controlling the dissemination of bacteria in health care settings, but it may also contribute to the selection of antibiotic resistance bacteria. This study looked at Klebsiella pneumoniae isolates collected from three hospitals in Lima, Peru, in order to evaluate: their susceptibility to chlorhexidine [CHG] and isopropanol [ISP]), and their association with antimicrobial susceptibility. We analyzed 59 K. pneumoniae isolates and assessed their CHG and ISP susceptibility by minimum inhibitory concentrations (MICs). Additionally, we performed a regression analysis to assess the association between disinfectant tolerance and antibiotic resistance (measured by the disc diffusion method), colistin resistance (by microdilution), carbapenemases presence (by polymerase chain reaction [PCR]), and clonal relationships (by pulsed-field gel electrophoresis [PFGE]). Eleven K. pneumoniae strains were isolated from fomites, and 48 strains from clinical samples. The MIC range of these isolates was 8–128 µg/ml for CHG and 16–256 mg/ml for ISP. We found that resistance to trimethoprim/sulfamethoxazole (TMP/SMX) was the main factor associated with CHG log2 MIC (ß = 0.65; 95%CI: 0.03, 1.27; R2 = 0.07). In the case of ISP, the log2(MIC) was associated with the institution of origin, showing lower ISP log2(MIC) in fomites compared to clinical samples(ß = −0.77; 95%CI: −1.54, −0.01; R2 = 0.08). Resistance to CHG and ISP among K. pneumoniae isolates found in Peruvian hospitals seems to be elevated and highly variable. Further studies are needed to confirm our results and implement actionable interventions if necessary.es_ES
dc.publisherUniversidad Continentales_ES
dc.subjectAlcohol desinfectantees_ES
dc.titleTolerance to disinfectants (chlorhexidine and isopropanol) and its association with antibiotic resistance in clinically-related Klebsiella pneumoniae isolateses_ES
dc.description.notePara acceder al artículo de su interés, puede solicitarlo a Por favor, comunicarse con su correo institucionales_ES
dc.identifier.journalPathogens and Global Healthes_ES
Appears in Collections:Artículos Científicos

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