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Repositorio Institucional Continental

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Title: Epigenetics of brain aging
Alternative Titles: Epigenética del envejecimiento cerebral
Authors: Cacabelos, R.
Teijido, O.
Keywords: Envejecimiento
Estructura de la cromatina
Publisher: Universidad Continental
Issue Date: 1-Jan-2018
Date available: 17-Jul-2020
Creation date: 2020
Bibliographic citation: Cacabelos, R., Teijido, O. (2018). Epigenetics of brain aging . Conn's Handbook of Models for Human Aging, 1(1), 1041-1065. https://doi. 10.1016/B978-0-12-811353-0.00074-9
DOI: 10.1016/B978-0-12-811353-0.00074-9
Abstract: The complexity of human aging and longevity results from a combination of genetic, epigenetic, and environmental factors. Epigenetic mechanisms, including DNA methylation, chromatin structure, and RNA interference, regulate gene expression and control the main metabolic pathways throughout life. This strict epigenetic management becomes progressively defective with age, which increases the risk for the onset of age-related pathologies. This chapter reviews the main alterations of the epigenetic machinery throughout life, with special focus on those affecting the aging brain, as well as the epigenetic control of life span by regulating telomere length and mitochondrial function, with special emphasis on the epigenetic interplay between nuclear and mitochondrial DNA. The last section summarizes the main epigenetic aberrations involving the most prevalent form of pathologic brain deterioration in elderly individuals, Alzheimer's disease, and novel potential epigenetic-based treatments.
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metadata.dc.format.extent: p. 1041-1065
Access: Restringido
Source: Universidad Continental
Repositorio Institucional - Continental
Appears in Collections:Capítulos de libros

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