Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12394/8504
Título: TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes
Autor(es): Velasco Chong, Jonas Roberto
Oscar Herrera Calderón
Juan Pedro Rojas Armas
Renán Dilton Hañari Quispe
Renán Dilton Hañari Quispe
Gilmar Peña Rojas
Vidalina Andía Ayme
Vidalina Andía Ayme
Andres F. Yepes Perez
Cristian Aguilar
Palabras clave: Productos agropecuarios
Editorial: Universidad Continental
Fecha de publicación: 2020
Fecha disponible: 25-feb-2021
Cita bibliográfica: Velasco, J., Herrera, O., Rojas, J., Hañari, R., Figueroa, l., Peña, G., Andía, V., Yuli, R., Yepes, A., Aguilar, C., (2020). TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes. Foods, 9(6). https://doi.org/10.3390/foods9060719
DOI: https://doi.org/10.3390/foods9060719
Resumen/Abstract: Potato tocosh is a naturally processed potato for nutritional and curative purposes from traditional Peruvian medicine. The aim of this study was to investigate the acute and sub-acute toxicity of tocosh flour (TF). For sub-acute toxicity, TF was administered orally to rats daily once a day for 28 days at doses of 1000 mg/kg body weight (BW). Animals were observed for general behaviors, mortality, body weight variations, and histological analysis. At the end of treatment, relative organ weights, histopathology, hematological and biochemical parameters were analyzed. For acute toxicity, TF was administered orally to mice at doses of 2000 and 5000 mg/kg BW at a single dose in both sexes. Body weight, mortality, and clinical signs were observed for 14 days after treatment. The results of acute toxicity showed that the median lethal dose (LD50) value of TF is higher than 2000 g/kg BW but less than 5000 mg/Kg BW in mice. Death and toxicological symptoms were not found during the treatment. For sub-acute toxicity, we found that no-observed-adverse-effect levels (NOAEL) of TF in rats up to 1000 g/kg BW. There were statistically significant differences in body weight, and relative organ weight in the stomach and brain. No differences in hematological and biochemical parameters were observed when compared with the control group. For sub-acute toxicity, histopathological studies revealed minor abnormalities in liver and kidney tissues at doses of 5000 mg/Kg. Based on these results, TF is a traditional Peruvian medicine with high safety at up to 1000 mg/kg BW for 28 days in rats.
Incluido en: https://www.mdpi.com/2304-8158/9/6/719/htm
Extensión: 16 páginas
Acceso: Acceso abierto
Fuente: Universidad Continental
Repositorio Institucional - Continental
Aparece en las colecciones: Artículos Científicos

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